Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus of young (4- to 6-month-old) PS1(M146L)/APP(751SL) mice model, as the initial dege...

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Detalhes bibliográficos
Main Authors: Sanchez-Varo, Raquel, Trujillo-Estrada, Laura, Sanchez-Mejias, Elisabeth, Torres, Manuel, Baglietto-Vargas, David, Moreno-Gonzalez, Ines, De Castro, Vanessa, Jimenez, Sebastian, Ruano, Diego, Vizuete, Marisa, Davila, Jose Carlos, Garcia-Verdugo, Jose Manuel, Jimenez, Antonio Jesus, Vitorica, Javier, Gutierrez, Antonia
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2011
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249205/
https://ncbi.nlm.nih.gov/pubmed/22020633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-011-0896-x
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