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Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia
Malignant hyperthermia (MH) susceptibility has been attributed to a leaky sarcoplasmic reticulum (SR) caused by missense mutations in RYR1 or CACNA1S, and the MH crisis has been attributed solely to massive self-sustaining release of Ca(2+) from SR stores elicited by triggering agents. Here, we show...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Federation of American Societies for Experimental Biology
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574284/ https://ncbi.nlm.nih.gov/pubmed/23159934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-218354 |
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