Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia

Malignant hyperthermia (MH) susceptibility has been attributed to a leaky sarcoplasmic reticulum (SR) caused by missense mutations in RYR1 or CACNA1S, and the MH crisis has been attributed solely to massive self-sustaining release of Ca(2+) from SR stores elicited by triggering agents. Here, we show...

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Detalhes bibliográficos
Main Authors: Eltit, José M., Ding, Xudong, Pessah, Isaac N., Allen, Paul D., Lopez, José R.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574284/
https://ncbi.nlm.nih.gov/pubmed/23159934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-218354
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