Englerin A stimulates PKCθ to inhibit insulin signaling and simultaneously activate HSF1: An example of pharmacologically induced synthetic lethality

The natural product englerin A (EA) binds to and activates protein kinase C-θ (PKCθ). EA-dependent activation of PKCθ induces an insulin resistant phenotype, limiting the access of tumor cells to glucose. At the same time, EA causes PKCθ-mediated phosphorylation and activation of the transcription f...

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Main Authors: Sourbier, Carole, Scroggins, Bradley T., Ratnayake, Ranjala, Prince, Thomas L., Lee, Sunmin, Lee, Min-Jung, Nagy, Peter Literati, Lee, Young H., Trepel, Jane B., Beutler, John A., Linehan, W. Marston, Neckers, Len
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574184/
https://ncbi.nlm.nih.gov/pubmed/23352416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.12.007
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