Synthesis of a Stable and Orally Bioavailable Englerin Analogue

Synthesis of analogues of englerin A with a reduced propensity for hydrolysis of the glycolate moiety led to a compound which possessed the renal cancer cell selectivity of the parent and was orally bioavailable in mice.

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Fash, David M., Peer, Cody J., Li, Zhenwu, Talisman, Ian J., Hayavi, Sima, Sulzmaier, Florian J., Ramos, Joe W., Sourbier, Carole, Neckers, Leonard, Figg, W. Douglas, Beutler, John A., Chain, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862412/
https://ncbi.nlm.nih.gov/pubmed/27107948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.04.016
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