Differential Effects of Drug Interventions and Dietary Lifestyle in Developing Type 2 Diabetes and Complications: A Systems Biology Analysis in LDLr−/− Mice

Excess caloric intake leads to metabolic overload and is associated with development of type 2 diabetes (T2DM). Current disease management concentrates on risk factors of the disease such as blood glucose, however with limited success. We hypothesize that normalizing blood glucose levels by itself i...

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Główni autorzy: Radonjic, Marijana, Wielinga, Peter Y., Wopereis, Suzan, Kelder, Thomas, Goelela, Varshna S., Verschuren, Lars, Toet, Karin, van Duyvenvoorde, Wim, van der Werff van der Vat, Bianca, Stroeve, Johanna H. M., Cnubben, Nicole, Kooistra, Teake, van Ommen, Ben, Kleemann, Robert
Format: Artigo
Język:Inglês
Wydane: Public Library of Science 2013
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574110/
https://ncbi.nlm.nih.gov/pubmed/23457508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056122
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