Prenatal Metformin Exposure in Mice Programs the Metabolic Phenotype of the Offspring during a High Fat Diet at Adulthood

AIMS: The antidiabetic drug metformin is currently used prior and during pregnancy for polycystic ovary syndrome, as well as during gestational diabetes mellitus. We investigated the effects of prenatal metformin exposure on the metabolic phenotype of the offspring during adulthood in mice. METHODS:...

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Main Authors: Salomäki, Henriikka, Vähätalo, Laura H., Laurila, Kirsti, Jäppinen, Norma T., Penttinen, Anna-Maija, Ailanen, Liisa, Ilyasizadeh, Juan, Pesonen, Ullamari, Koulu, Markku
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574083/
https://ncbi.nlm.nih.gov/pubmed/23457588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056594
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