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Abraxas and Rap80 form a novel BRCA1 protein complex required for the DNA damage response
The BRCT repeats of BRCA1 are essential for tumor suppression. Phospho-peptide affinity proteomic analysis identified a novel protein, Abraxas, that directly binds the BRCA1 BRCT repeats through a phospho-SXXF motif. Abraxas binds BRCA1 mutually exclusively with BACH1 and CTIP, forming a third Brca1...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3573690/ https://ncbi.nlm.nih.gov/pubmed/17525340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1139476 |
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