Bovine lactoferricin induces TIMP-3 via the ERK1/2-Sp1 axis in human articular chondrocytes

Bovine lactoferricin (LfcinB) is a heparan sulfate-binding peptide with multiple bioactivities. In human articular cartilage, LfcinB antagonizes interleukin-1 β (IL-1β) and fibroblast growth factor 2 (FGF-2) in proteoglycan metabolism, catabolic protease expression, and induction of pro-inflammatory...

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Huvudupphovsmän: Yan, Dongyao, Chen, Di, Hawse, John R, van Wijnen, Andre J, Im, Hee-Jeong
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573330/
https://ncbi.nlm.nih.gov/pubmed/23313877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2013.01.001
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