Pioglitazone Attenuates Valvular Calcification Induced by Hypercholesterolemia

OBJECTIVE: Development of calcific aortic valve stenosis (CAVS) involves multiple signaling pathways, which may be modulated by peroxisome proliferator-activated receptor-gamma (PPARγ). This study tested the hypothesis that pioglitazone, a ligand for PPARγ, inhibits calcification of the aortic valve...

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Bibliografiske detaljer
Main Authors: Chu, Yi, Lund, Donald D., Weiss, Robert M., Brooks, Robert M., Doshi, Hardik, Hajj, Georges P., Sigmund, Curt D., Heistad, Donald D.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573264/
https://ncbi.nlm.nih.gov/pubmed/23288158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300794
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