A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma

Glioblastoma, the most common primary malignant brain tumor, is incurable with current therapies. Genetic and molecular analyses demonstrate that glioblastomas frequently display mutations that activate receptor tyrosine kinase (RTK) and Pi-3 kinase (PI3K) signaling pathways. In Drosophila melanogas...

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Detalhes bibliográficos
Main Authors: Read, Renee D., Fenton, Tim R., Gomez, German G., Wykosky, Jill, Vandenberg, Scott R., Babic, Ivan, Iwanami, Akio, Yang, Huijun, Cavenee, Webster K., Mischel, Paul S., Furnari, Frank B., Thomas, John B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573097/
https://ncbi.nlm.nih.gov/pubmed/23459592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003253
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