Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection

Type I Interferons (IFN-I) promote antiviral CD8(+)T cell responses, but the contribution of different IFN-I sources and signaling pathways are ill-defined. While plasmacytoid dendritic cells (pDCs) produce IFN-I upon TLR stimulation, IFN-I are induced in most cells by helicases like MDA5. Using acu...

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Bibliographic Details
Main Authors: Wang, Yaming, Swiecki, Melissa, Cella, Marina, Alber, Gottfried, Schreiber, Robert D, Gilfillan, Susan, Colonna, Marco
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572910/
https://ncbi.nlm.nih.gov/pubmed/22704623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.05.003
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