Mitochondrial DNA Mutations in Mutator Mice Confer Respiration Defects and B-Cell Lymphoma Development

Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes accelerated accumulation of random mutations in mtDNA, r...

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Detalhes bibliográficos
Main Authors: Mito, Takayuki, Kikkawa, Yoshiaki, Shimizu, Akinori, Hashizume, Osamu, Katada, Shun, Imanishi, Hirotake, Ota, Azusa, Kato, Yukina, Nakada, Kazuto, Hayashi, Jun-Ichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572082/
https://ncbi.nlm.nih.gov/pubmed/23418460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055789
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