Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

Age-associated accumulation of somatic mutations in mitochondrial DNA (mtDNA) has been proposed to be responsible for the age-associated mitochondrial respiration defects found in elderly human subjects. We carried out reprogramming of human fibroblast lines derived from elderly subjects by generati...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hashizume, Osamu, Ohnishi, Sakiko, Mito, Takayuki, Shimizu, Akinori, Ishikawa, Kaori, Nakada, Kazuto, Soda, Manabu, Mano, Hiroyuki, Togayachi, Sumie, Miyoshi, Hiroyuki, Okita, Keisuke, Hayashi, Jun-Ichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377050/
https://ncbi.nlm.nih.gov/pubmed/26000717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10434
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