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Mitochondrial DNA with a Large-Scale Deletion Causes Two Distinct Mitochondrial Disease Phenotypes in Mice

Studies in patients have suggested that the clinical phenotypes of some mitochondrial diseases might transit from one disease to another (e.g., Pearson syndrome [PS] to Kearns-Sayre syndrome) in single individuals carrying mitochondrial (mt) DNA with a common deletion (∆mtDNA), but there is no direc...

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Detalhes bibliográficos
Main Authors: Katada, Shun, Mito, Takayuki, Ogasawara, Emi, Hayashi, Jun-Ichi, Nakada, Kazuto
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755915/
https://ncbi.nlm.nih.gov/pubmed/23853091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.113.007245
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