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Analysis of the Costructure of the Simian Virus 40 T-Antigen Origin Binding Domain with Site I Reveals a Correlation between GAGGC Spacing and Spiral Assembly

Polyomavirus origins of replication contain multiple occurrences of G(A/G)GGC, the high-affinity binding element for the viral initiator T-antigen (T-ag). The site I regulatory region of simian virus 40, involved in the repression of transcription and the enhancement of DNA replication initiation, c...

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Detalhes bibliográficos
Main Authors: Meinke, Gretchen, Phelan, Paul J., Harrison, Celia J., Bullock, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571380/
https://ncbi.nlm.nih.gov/pubmed/23269808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02549-12
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