Structure-Based Analysis of the Interaction between the Simian Virus 40 T-Antigen Origin Binding Domain and Single-Stranded DNA

The origin-binding domain (OBD) of simian virus 40 (SV40) large T-antigen (T-Ag) is essential for many of T-Ag's interactions with DNA. Nevertheless, many important issues related to DNA binding, for example, how single-stranded DNA (ssDNA) transits along the T-Ag OBD, have yet to be establishe...

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Autores principales: Meinke, Gretchen, Phelan, Paul J., Fradet-Turcotte, Amélie, Bohm, Andrew, Archambault, Jacques, Bullock, Peter A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2011
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020010/
https://ncbi.nlm.nih.gov/pubmed/20980496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01738-10
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