Model for T-Antigen-Dependent Melting of the Simian Virus 40 Core Origin Based on Studies of the Interaction of the Beta-Hairpin with DNA

The interaction of simian virus 40 (SV40) T antigen (T-ag) with the viral origin has served as a model for studies of site-specific recognition of a eukaryotic replication origin and the mechanism of DNA unwinding. These studies have revealed that a motif termed the “beta-hairpin” is necessary for a...

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Detalhes bibliográficos
Main Authors: Kumar, Anuradha, Meinke, Gretchen, Reese, Danielle K., Moine, Stephanie, Phelan, Paul J., Fradet-Turcotte, Amélie, Archambault, Jacques, Bohm, Andrew, Bullock, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900137/
https://ncbi.nlm.nih.gov/pubmed/17287270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02451-06
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