Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing

BACKGROUND: Reduced representation bisulfite sequencing (RRBS) was developed to measure DNA methylation of high-CG regions at single base-pair resolution, and has been widely used because of its minimal DNA requirements and cost efficacy; however, the CpG coverage of genomic regions is restricted an...

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Main Authors: Wang, Junwen, Xia, Yudong, Li, Lili, Gong, Desheng, Yao, Yu, Luo, Huijuan, Lu, Hanlin, Yi, Na, Wu, Honglong, Zhang, Xiuqing, Tao, Qian, Gao, Fei
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2013
Ábhair:
Methodology Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570491/
https://ncbi.nlm.nih.gov/pubmed/23324053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-11
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