Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment

The cytokine thrombopoietin (TPO), the ligand for the hematopoietic receptor c-Mpl, acts as a primary regulator of megakaryocytopoiesis and platelet production. We have determined the crystal structure of the receptor-binding domain of human TPO (hTPO(163)) to a 2.5-Å resolution by complexation with...

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מידע ביבליוגרפי
Main Authors: Feese, Michael D., Tamada, Taro, Kato, Yoichi, Maeda, Yoshitake, Hirose, Masako, Matsukura, Yasuko, Shigematsu, Hideki, Muto, Takanori, Matsumoto, Atsushi, Watarai, Hiroshi, Ogami, Kinya, Tahara, Tomoyuki, Kato, Takashi, Miyazaki, Hiroshi, Kuroki, Ryota
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2004
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC357010/
https://ncbi.nlm.nih.gov/pubmed/14769915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308530100
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