Thrombin cleaves recombinant human thrombopoietin: One of the proteolytic events that generates truncated forms of thrombopoietin

A heterogeneity in the molecular weight (M(r)) of thrombopoietin (TPO) has been reported. We found several thrombin cleavage sites in human, rat, murine, and canine TPOs, and also found that human TPO undergoes selective proteolysis by thrombin. Recombinant human TPO (rhTPO) was incubated with human...

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Hlavní autoři: Kato, Takashi, Oda, Atsushi, Inagaki, Yoshimasa, Ohashi, Hideya, Matsumoto, Atsushi, Ozaki, Katsutoshi, Miyakawa, Yoshitaka, Watarai, Hiroshi, Fuju, Kazumi, Kokubo, Atsuko, Kadoya, Toshihiko, Ikeda, Yasuo, Miyazaki, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences of the USA 1997
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC20782/
https://ncbi.nlm.nih.gov/pubmed/9114049
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