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Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex

A crystal structure of the signaling complex between human granulocyte colony-stimulating factor (GCSF) and a ligand binding region of GCSF receptor (GCSF-R), has been determined to 2.8 Å resolution. The GCSF:GCSF-R complex formed a 2:2 stoichiometry by means of a cross-over interaction between the...

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Autors principals: Tamada, Taro, Honjo, Eijiro, Maeda, Yoshitake, Okamoto, Tomoyuki, Ishibashi, Matsujiro, Tokunaga, Masao, Kuroki, Ryota
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413920/
https://ncbi.nlm.nih.gov/pubmed/16492764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511264103
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