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Enzyme-Specific Activation versus Leaving Group Ability
Enzyme-specific activation and the substrate mimetics strategy are effective ways to circumvent the limited substrate recognition often encountered in protease-catalyzed peptide synthesis. A key structural element in both approaches is the guanidinophenyl (OGp) ester, which enables important interac...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
WILEY-VCH Verlag
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3569868/ https://ncbi.nlm.nih.gov/pubmed/22821810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200227 |
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