Enzyme-Specific Activation versus Leaving Group Ability

Enzyme-specific activation and the substrate mimetics strategy are effective ways to circumvent the limited substrate recognition often encountered in protease-catalyzed peptide synthesis. A key structural element in both approaches is the guanidinophenyl (OGp) ester, which enables important interac...

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Autors principals: de Beer, Roseri J A C, Bögels, Berry, Schaftenaar, Gijs, Zarzycka, Barbara, Quaedflieg, Peter J L M, van Delft, Floris L, Nabuurs, Sander B, Rutjes, Floris P J T
Format: Artigo
Idioma:Inglês
Publicat: WILEY-VCH Verlag 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569868/
https://ncbi.nlm.nih.gov/pubmed/22821810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200227
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