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Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults
Genome-wide association studies identified GLIS3 as a susceptibility locus for type 1 and type 2 diabetes. Global Glis3 deficiency in mice leads to congenital diabetes and neonatal lethality. In this study, we explore the role of Glis3 in adulthood using Glis3(+/−) and conditional knockout animals....
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
WILEY-VCH Verlag
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3569656/ https://ncbi.nlm.nih.gov/pubmed/23197416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201398 |
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