Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice

We previously showed that adipose differentiation related protein (Adfp)-deficient mice display a 60% reduction in hepatic triglyceride (TG) content. In this study, we investigated the role of ADFP in lipid and glucose homeostasis in a genetic obesity model, Lep(ob/ob) mice. We bred Adfp(−/−) mice w...

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Hlavní autoři: Chang, Benny Hung-Junn, Li, Lan, Saha, Pradip, Chan, Lawrence
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2010
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903828/
https://ncbi.nlm.nih.gov/pubmed/20424269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M004515
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