The Effect of the Disease-Causing R266K Mutation on the Heme and PLP Environments of Human Cystathionine β-Synthase

Cystathionine β-synthase (CBS) is an essential PLP-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function. Herein we describe the enzymatic and spectroscopic propertie...

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Hauptverfasser: Smith, Aaron T., Su, Yang, Stevens, Daniel J., Majtan, Tomas, Kraus, Jan P., Burstyn, Judith N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569099/
https://ncbi.nlm.nih.gov/pubmed/22738154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300421z
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