Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain

OBJECTIVE: Vessels in brain arteriovenous malformations (bAVM) are prone to rupture. The underlying pathogenesis is not clear. Hereditary hemorrhagic telangiectasia type 2 (HHT2) patients with activin receptor-like kinase 1 (Alk1) mutation have a higher incidence of bAVM than the general population....

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Main Authors: Chen, Wanqiu, Guo, Yi, Walker, Espen J., Shen, Fanxia, Jun, Kristine, Oh, S. Paul, Degos, Vincent, Lawton, Michael T., Tihan, Tarik, Davalos, Dimitrios, Akassoglou, Katerina, Nelson, Jeffrey, Pile-Spellman, John, Su, Hua, Young, William L.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569037/
https://ncbi.nlm.nih.gov/pubmed/23241407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300485
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