Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

Alpha-synucleinopathies (ASP) are neurodegenerative disorders, characterized by accumulation of misfolded α-synuclein, selective neuronal loss, and extensive gliosis. It is accepted that microgliosis and astrogliosis contribute to the disease progression in ASP. Toll-like receptors (TLRs) are expres...

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Hlavní autoři: Fellner, Lisa, Irschick, Regina, Schanda, Kathrin, Reindl, Markus, Klimaschewski, Lars, Poewe, Werner, Wenning, Gregor K, Stefanova, Nadia
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2013
Témata:
Original Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568908/
https://ncbi.nlm.nih.gov/pubmed/23108585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22437
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