Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis

BACKGROUND: The progressive neurodegenerative disorder multiple system atrophy (MSA) is characterized by α-synuclein-positive (oligodendro-) glial cytoplasmic inclusions (GCIs). A connection between the abnormal accumulation of α-synuclein in GCIs and disease initiation and progression has been post...

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Vydáno v:BMC Neurosci
Hlavní autoři: Fellner, Lisa, Buchinger, Edith, Brueck, Dominik, Irschick, Regina, Wenning, Gregor K., Stefanova, Nadia
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963177/
https://ncbi.nlm.nih.gov/pubmed/29783943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-018-0431-2
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