Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

Toll-like receptors (TLRs) mediate innate immunity, and their dysregulation may play a role in α-synucleinopathies, such as Parkinson's disease or multiple system atrophy (MSA). The aim of this study was to define the role of TLR4 in α-synuclein–linked neurodegeneration. Ablation of TLR4 in a t...

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Bibliografiske detaljer
Main Authors: Stefanova, Nadia, Fellner, Lisa, Reindl, Markus, Masliah, Eliezer, Poewe, Werner, Wenning, Gregor K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2011
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157205/
https://ncbi.nlm.nih.gov/pubmed/21801874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.04.013
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