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The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes

The critical role of cytotoxic lymphocyte antigen 4 (CTLA-4) in inhibiting antigen-driven T cell responses upon engagement with its ligands, B7-1 and B7-2, and its importance for peripheral T cell tolerance and T cell homeostasis has been studied intensively. The CTLA-4 splice variant, li-CTLA-4 is...

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Autors principals: Stumpf, Melanie, Zhou, Xuyu, Bluestone, Jeffrey A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568535/
https://ncbi.nlm.nih.gov/pubmed/23293354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201362
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