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Helices 2 and 3 are the initiation sites in the PrP(C) → PrP(SC) transition
It is established that prion protein is the sole causative agent in a number of diseases in humans and animals. However, the nature of conformational changes that the normal cellular form PrP(C) undergoes in the conversion process to a self-replicating state is still not fully understood. The ordere...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3568509/ https://ncbi.nlm.nih.gov/pubmed/23256626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3005472 |
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