Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining

Classical nonhomologous end joining (C-NHEJ) is a major mammalian DNA double-strand break (DSB) repair pathway that is required for assembly of antigen receptor variable region gene segments by V(D)J recombination. Recombination activating gene endonuclease initiates V(D)J recombination by generatin...

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Dettagli Bibliografici
Autori principali: Oksenych, Valentyn, Kumar, Vipul, Liu, Xiangyu, Guo, Chunguang, Schwer, Bjoern, Zha, Shan, Alt, Frederick W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568359/
https://ncbi.nlm.nih.gov/pubmed/23345432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222573110
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