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Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70

DNA double-strand breaks (DSBs) are recognized and repaired by the Classical Non-Homologous End-Joining (C-NHEJ) and Homologous Recombination pathways. C-NHEJ includes the core Ku70 and Ku80 (or Ku86) heterodimer that binds DSBs and thus promotes recruitment of accessory downstream NHEJ factors XLF,...

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Detalhes bibliográficos
Publicado no:DNA Repair (Amst)
Main Authors: Xing, Mengtan, Bjørås, Magnar, Daniel, Jeremy A., Alt, Frederick W., Oksenych, Valentyn
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584571/
https://ncbi.nlm.nih.gov/pubmed/28759779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.07.008
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