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Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70
DNA double-strand breaks (DSBs) are recognized and repaired by the Classical Non-Homologous End-Joining (C-NHEJ) and Homologous Recombination pathways. C-NHEJ includes the core Ku70 and Ku80 (or Ku86) heterodimer that binds DSBs and thus promotes recruitment of accessory downstream NHEJ factors XLF,...
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| 發表在: | DNA Repair (Amst) |
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| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5584571/ https://ncbi.nlm.nih.gov/pubmed/28759779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.07.008 |
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