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ATM Damage Response and XLF Repair Factor are Functionally Redundant In Joining DNA Breaks
Classical non-homologous DNA end-joining (C-NHEJ) is a major mammalian DNA double strand break (DSB) repair pathway. Deficiencies for C-NHEJ factors, such as XRCC4, abrogate lymphocyte development, owing to a strict requirement for C-NHEJ to join V(D)J recombination DSB intermediates1,2. The XRCC4-l...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2010
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3058373/ https://ncbi.nlm.nih.gov/pubmed/21160472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09604 |
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