ATM Damage Response and XLF Repair Factor are Functionally Redundant In Joining DNA Breaks

Classical non-homologous DNA end-joining (C-NHEJ) is a major mammalian DNA double strand break (DSB) repair pathway. Deficiencies for C-NHEJ factors, such as XRCC4, abrogate lymphocyte development, owing to a strict requirement for C-NHEJ to join V(D)J recombination DSB intermediates1,2. The XRCC4-l...

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Hlavní autoři: Zha, Shan, Guo, Chunguang, Boboila, Cristian, Oksenych, Valentyn, Cheng, Hwei-Ling, Zhang, Yu, Wesemann, Duane R., Yuen, Grace, Patel, Harin, Goff, Peter H., Dubois, Richard L., Alt, Frederick W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058373/
https://ncbi.nlm.nih.gov/pubmed/21160472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09604
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