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Structures of a Na(+)-coupled, substrate-bound MATE multidrug transporter
Multidrug transporters belonging to the multidrug and toxic compound extrusion (MATE) family expel dissimilar lipophilic and cationic drugs across cell membranes by dissipating a preexisting Na(+) or H(+) gradient. Despite its clinical relevance, the transport mechanism of MATE proteins remains poor...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3568332/ https://ncbi.nlm.nih.gov/pubmed/23341609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219901110 |
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