Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1(MET)

Ectodermal dysplasia is a group of congenital syndromes affecting a variety of ectodermal derivatives. Among them, ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome is caused by single point mutations in the p63 gene, which controls epidermal development and homeostasis. Phenot...

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Autores principales: Shalom-Feuerstein, Ruby, Serror, Laura, Aberdam, Edith, Müller, Franz-Josef, van Bokhoven, Hans, Wiman, Klas G., Zhou, Huiqing, Aberdam, Daniel, Petit, Isabelle
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568301/
https://ncbi.nlm.nih.gov/pubmed/23355677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201753109
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