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Correlated Evolution of Positions within Mammalian cis Elements

Transcriptional regulation critically depends on proper interactions between transcription factors (TF) and their cognate DNA binding sites. The widely used model of TF-DNA binding – the Positional Weight Matrix (PWM) – presumes independence between positions within the binding site. However, there...

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Detalhes bibliográficos
Main Authors: Mukherjee, Rithun, Evans, Perry, Singh, Larry N., Hannenhalli, Sridhar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568137/
https://ncbi.nlm.nih.gov/pubmed/23408994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055521
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