The pH Sensitivity of Murine Heat Shock Protein 47 (HSP47) Binding to Collagen Is Affected by Mutations in the Breach Histidine Cluster

Heat shock protein 47 (HSP47) is a single-substrate molecular chaperone crucial for collagen biosynthesis. Although its function is well established, the molecular mechanisms that govern binding to procollagen peptides and triple helices in the endoplasmic reticulum (followed by controlled release i...

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Bibliographische Detailangaben
Hauptverfasser: Abdul-Wahab, Mohd Firdaus, Homma, Takayuki, Wright, Michael, Olerenshaw, Dee, Dafforn, Timothy R., Nagata, Kazuhiro, Miller, Andrew D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567694/
https://ncbi.nlm.nih.gov/pubmed/23212911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.409029
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