α-Hemoglobin Stabilizing Protein (AHSP) Markedly Decreases the Redox Potential and Reactivity of α-Subunits of Human HbA with Hydrogen Peroxide

α-Hemoglobin stabilizing protein (AHSP) is a molecular chaperone that binds monomeric α-subunits of human hemoglobin A (HbA) and modulates heme iron oxidation and subunit folding states. Although AHSP·αHb complexes autoxidize more rapidly than HbA, the redox mechanisms appear to be similar. Both met...

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Autores principales: Mollan, Todd L., Banerjee, Sambuddha, Wu, Gang, Parker Siburt, Claire J., Tsai, Ah-Lim, Olson, John S., Weiss, Mitchell J., Crumbliss, Alvin L., Alayash, Abdu I.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Molecular Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567680/
https://ncbi.nlm.nih.gov/pubmed/23264625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.412064
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