Oxidative instability of hemoglobin E (β26 Glu→Lys) is increased in the presence of free α subunits and reversed by α-hemoglobin stabilizing protein (AHSP): Relevance to HbE/β-thalassemia()

When adding peroxide (H(2)O(2)), β subunits of hemoglobin (Hb) bear the burden of oxidative changes due in part to the direct oxidation of its Cys93. The presence of unpaired α subunits within red cells and/or co-inheritance of another β subunit mutant, HbE (β26 Glu→Lys) have been implicated in the...

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Udgivet i:Redox Biol
Main Authors: Strader, Michael Brad, Kassa, Tigist, Meng, Fantao, Wood, Francine B., Hirsch, Rhoda Elison, Friedman, Joel M., Alayash, Abdu I.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4804395/
https://ncbi.nlm.nih.gov/pubmed/26995402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.03.004
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