Scaffolding by A-Kinase Anchoring Protein Enhances Functional Coupling between Adenylyl Cyclase and TRPV1 Channel

Scaffolding proteins often bring kinases together with their substrates to facilitate cell signaling. This arrangement is critical for the phosphorylation and regulation of the transient receptor potential vanilloid 1 (TRPV1) channel, a key target of inflammatory mediators such as prostaglandins. Th...

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Détails bibliographiques
Auteurs principaux: Efendiev, Riad, Bavencoffe, Alexis, Hu, Hongzhen, Zhu, Michael X., Dessauer, Carmen W.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567646/
https://ncbi.nlm.nih.gov/pubmed/23264624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.428144
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