Regulation of interleukin-6 secretion by the two-pore-domain potassium channel Trek-1 in alveolar epithelial cells

We recently proposed a role for the two-pore-domain K(+) (K2P) channel Trek-1 in the regulation of cytokine release from mouse alveolar epithelial cells (AECs) by demonstrating decreased interleukin-6 (IL-6) secretion from Trek-1-deficient cells, but the underlying mechanisms remained unknown. This...

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Main Authors: Schwingshackl, Andreas, Teng, Bin, Ghosh, Manik, Lim, Keng Gat, Tigyi, Gabor, Narayanan, Damodaran, Jaggar, Jonathan H., Waters, Christopher M.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567358/
https://ncbi.nlm.nih.gov/pubmed/23275623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00299.2012
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