Altered Cohesin Gene Dosage Affects Mammalian Meiotic Chromosome Structure and Behavior

Based on studies in mice and humans, cohesin loss from chromosomes during the period of protracted meiotic arrest appears to play a major role in chromosome segregation errors during female meiosis. In mice, mutations in meiosis-specific cohesin genes cause meiotic disturbances and infertility. Howe...

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Autors principals: Murdoch, Brenda, Owen, Nichole, Stevense, Michelle, Smith, Helen, Nagaoka, So, Hassold, Terry, McKay, Michael, Xu, Huiling, Fu, Jun, Revenkova, Ekaterina, Jessberger, Rolf, Hunt, Patricia
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567145/
https://ncbi.nlm.nih.gov/pubmed/23408896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003241
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