dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. We previously showed that the expression of dynactin 1, an axon motor protein regulating retrograde transport, is markedly reduced in spinal motor neurons of sporadic ALS...

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Detaylı Bibliyografya
Asıl Yazarlar: Ikenaka, Kensuke, Kawai, Kaori, Katsuno, Masahisa, Huang, Zhe, Jiang, Yue-Mei, Iguchi, Yohei, Kobayashi, Kyogo, Kimata, Tsubasa, Waza, Masahiro, Tanaka, Fumiaki, Mori, Ikue, Sobue, Gen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567092/
https://ncbi.nlm.nih.gov/pubmed/23408943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054511
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