dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. We previously showed that the expression of dynactin 1, an axon motor protein regulating retrograde transport, is markedly reduced in spinal motor neurons of sporadic ALS...

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Библиографические подробности
Главные авторы: Ikenaka, Kensuke, Kawai, Kaori, Katsuno, Masahisa, Huang, Zhe, Jiang, Yue-Mei, Iguchi, Yohei, Kobayashi, Kyogo, Kimata, Tsubasa, Waza, Masahiro, Tanaka, Fumiaki, Mori, Ikue, Sobue, Gen
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567092/
https://ncbi.nlm.nih.gov/pubmed/23408943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054511
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