dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. We previously showed that the expression of dynactin 1, an axon motor protein regulating retrograde transport, is markedly reduced in spinal motor neurons of sporadic ALS...

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Main Authors: Ikenaka, Kensuke, Kawai, Kaori, Katsuno, Masahisa, Huang, Zhe, Jiang, Yue-Mei, Iguchi, Yohei, Kobayashi, Kyogo, Kimata, Tsubasa, Waza, Masahiro, Tanaka, Fumiaki, Mori, Ikue, Sobue, Gen
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567092/
https://ncbi.nlm.nih.gov/pubmed/23408943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054511
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