Interconverting Conformations of Slipped-DNA Junctions Formed by Trinucleotide Repeats Affect Repair Outcome

[Image: see text] Expansions of (CTG)·(CAG) repeated DNAs are the mutagenic cause of 14 neurological diseases, likely arising through the formation and processing of slipped-strand DNAs. These transient intermediates of repeat length mutations are formed by out-of-register mispairing of repeat units...

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Hauptverfasser: Slean, Meghan M., Reddy, Kaalak, Wu, Bin, Nichol Edamura, Kerrie, Kekis, Mariana, Nelissen, Frank H. T., Aspers, Ruud L. E. G., Tessari, Marco, Schärer, Orlando D., Wijmenga, Sybren S., Pearson, Christopher E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566650/
https://ncbi.nlm.nih.gov/pubmed/23339280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301369b
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